LDLR KO高脂誘導模型
Ldlr KO高脂誘導模型Ldlr KO小鼠血清膽固醇水平,是野生小鼠的2~4倍。結合高脂(HFD-fed)飼喂Ldlr KO小鼠,可以誘導以肥胖、高膽固醇血癥為特征的代謝綜合征、高甘油三酯血癥和胰島素抵抗癥狀;類似于人NASH模型為特征的模型。參考文獻(1)Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.Cell Mol Gastroenterol Hepatol. 2017 Oct 14;5(1): 83-98. e10. doi: 10.1016/j.jcmgh.2017.10.001. eCollection 2018.